There are many different hard ships that we as people face every day and also throughout our lives, both accepting what others do and seeking the acceptance of others can be considered as one of those many hard ships. Within book one the idea of change is presented right away by Cal as he reflects on his past in which he states “I was born twice: first, as a baby girl, on a remarkably smogless Detroit day in January of 1960; and then again, as a teenage boy, in an emergency room near Petoskey, Michigan, in August of 1974″( Book 1, pg.3) . Change was inevitable for Cal and whether or not society agreed it was a necessary decision that had to be made. Society forms its own opinions towards every type of person regardless of race, sex, gender and or background. The issue that is brought out in Middlesex helps to show the fear and hope for acceptance from people that have been labeled “different”. Cal did not choose to be born in the position that he was given while his parents knew the possible consequences from the decision they were making to have a child. Desdemona and Lefty were two normal people with two very normal lives, Lefty is an example of a guy who found pleasure in one night stands and could be seen as a more care free person. Desdemona in contrast seems to think a little more about her choices and where they will eventually lead. Lefty and Desdemona find what they think to be love in each other as third cousins and soon face a world in which they are shunned from society. Biologically their decision was wrong as well as culturally and as a result they flee to America to recreate themselves but the problems do not stop there, but later continue when they have a grandchild born with a sexual deficiency. Even though they may have ran from the original problems they faced things continued on with their own grandson, they had failed at their own acceptance and felt as though Cal would have to deal with a lifetime filled with the same battle.